个人简介：
解晓东，男，生于1991.01。 7003全讯论坛助理研究员，医学博士，福州海洋药物研发行业技术创新中心主任，福建省生物医学工程理事，主要从事生物医药，肿瘤检测，肿瘤靶向治疗，免疫治疗等。在Nature Communications, Advanced Functional Materials, Journal of Controlled Release, Nano Today，Signal Transduction and Targeted Therapy等国际知名期刊上以第一作者发表多篇论文。主持了包括国家自然科学基金青年项目、福建省自然科学基金青年项目在内的多项项目。
教育经历：
2009.09-2013.06 武汉纺织大学 生物工程专业本科
2013.09-2016.06 福州大学 生物化工专业 硕士
2016.09-2020.06 福州大学 药物分析学专业 博士
2019.01-2020.08 美国加州大学洛杉矶分校 联合培养博士
工作经历
2021.04-至今 7003全讯论坛全讯白菜网 助理研究员
2023.08-2024.08 新加坡国立大学 访问学者
社会工作
2022年-至今 福建省生物医学工程学会 理事
2023年-至今 Frontiers in Bioengineering and Biotechnology 客座编辑
获得荣誉
2022年 第十五届福建省自然科学优秀学术论文一等奖
2023年 福建省高层次C类人才
2023年 福建省自然科学技术奖三等奖
2024年 第十七届福建省自然科学优秀学术论文二等奖
主要参与的项目
1.基于肿瘤外泌体的肺癌综合诊断系统， 福建省自然科学基金项目(青年创新 2021J05210 )， 2021/2024。（主持）
2.基于工程化外泌体的长效纳米发生器用于结肠癌的组合治疗研究。国家自然科学基金青年项目 (82202355)，2023.01.01-至今；（主持）
3.基于肿瘤外泌体血液活检的多靶向纳米阵列用于乳腺癌的早期广谱检测。发树慈善基金（MFK24018）2024.09-2027.09;(主持)
4.基于生物纳米材料技术调控细胞生长周期的试剂盒开发。横向项目（20万，主持）
5.肺癌在体分子分型的新型纳米分子成像探针基础研究之基于在体分子分型的肺癌个体化治疗及评价。国家“973”项目（项目编号：2015CB931804）2015.01-2019.12。（参与）
6. pH/乏氧双重响应分子靶向纳米载体可视化多途径联合抗非小细胞肺癌研究。国家自然科学基金（项目编号：81871481）, 2019.01-2022.12。（参与）
7. 基于一氧化氮通过改善血液微环境干预肿瘤血路转移的分子机制研究。国家自然青年基金项目（项目编号：81703555）,24万，2018.01-2020.12。（参与）
8. 智能响应成像型分子靶向/基因治疗联用纳米给药系统一体化诊疗EGFR突变型肺癌研究。国家自然科学基金项目（项目编号：81571802），69.4万，2016.01-2019.12。（参与）
主要成果（文章、专利等）
1.Junqing Lin, Zhenhu Lin, Leilei Liu, Wenjin Lin, Xiaodong Xie* , Xiujuan Zhang* Enhancing glioma-specific drug delivery through self-assembly of macrophage membrane and targeted polymer assisted by low-frequency ultrasound irradiation. Materials Today Bio 26 (2024) 101067.(IF=8.7)
2.Shu Lian, Qixuan Wang, Yuxin Liu, Yusheng Lu, Lu Huang,*, Haohua Deng c*, Xiaodong Xie* Multi-targeted nanoarrays for early broad-spectrum detection of lung cancer based on blood biopsy of tumor exosomes. Talanta 276 (2024) 126270. (IF=5.6)
3.Xiaodong Xie, Yumei Li, Shu Lian, Yusheng Lu and Lee Jia.Cancer metastasis chemoprevention prevents circulating tumour cells from germination, Signal Transduction and Targeted Therapy,(2022) 7:341.（IF=38.104）
4.Xiaodong Xie;Jinhong Jiang;Xiangsheng Liu; Yuhong Cao; Jiulong Li; Tian Xia; Huan Meng.Interleukin-10 plasmid delivery by polymeric nanocarrier shows efficient and safe tissue repair in acute muscle damage models in mice. Nano Today, 2022, 46:101544.（IF=18.962）
5.Xiangsheng Liu#, Xiaodong Xie#, Jinhong Jiang, Matthew Lin, Emily Zheng, Waveley Qiu, Iwin Yeung, Motao Zhu, Qinglin Li, Tian Xia, and Huan Meng. Use of Nanoformulation to Target Macrophages for Disease Treatment. Adv. Funct. Mater. 2021, 2104487.（IF=19.924）
6.Xiaodong Xie; Shu Lian; Yu Zhou; Bifei Li; Yusheng Lu; Iwin Yeung; Lee Jia ; Tumor-derived exosomes can specifically prevent cancer metastatic organotropism, Journal of Controlled Release, 2021, 331: 404-415.（IF=11.467）
7.Xiaodong Xie ; Huifang Nie; Yu Zhou; Shu Lian; Hao Mei; Yusheng Lu; Haiyan Dong; Fengqiao Li; Tao Li; Bifei Li; Jie Wang; Min Lin; Chaihung Wang; Jingwei Shao; Yu Gao; Jianming Chen; Fang wei Xie; Lee Jia ; Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles, Nature Communications, 2019, 10: 5476 （IF=17.694）
8.Xiaodong Xie; Fengqiao Li; Huijuan Zhang; Yusheng Lu; Shu Lian; Hang Lin; Yu Gao; Lee Jia; EpCAM aptamer-functionalized mesoporous silica nanoparticles for efficient colon cancer cell-targeted drug delivery, European Journal of Pharmaceutical Sciences, 2016, 83(83): 28-35（IF=5.112）被引用159次
9.Huifang Nie#; Xiaodong Xie#; Doudou Zhang; Yu Zhou; Bifei Li; Fengqiao Li; Feiyang Li; Yunlong Cheng; Hao Mei; Huan Meng; Lee Jia ; Use of lung-specific exosomes for miRNA-126 delivery in non-small cell lung cancer, Nanoscale, 2020, 12(2): 877-887（IF=8.307）ESI高被引论文 164次
10.Shu Lian; Ruizhi Xie; Yuying Ye; Xiaodong Xie; Shuhui Li; Yusheng Lu; Bifei Li; Yunlong Cheng; Vladimir L.Katanaev; Lee Jia ; Simultaneous blocking of CD47 and PD-L1 increases innate and adaptive cancer immune responses and cytokine release, EBioMedicine, 2019, 42: 295 （IF=11.205）
11.Xiaodong Xie#, Yingying Zhang#, Yu Gao*,et al. Challenges and opportunities from basic cancer biology for nanomedicine for targeted drug delivery.Current Cancer Drug Targets. doi:10.2174/1568009618666180628160211.（IF=2.907）
12.Ying Ji, Xiangsheng Liu, Juan Li, Xiaodong Xie, et al. Use of ratiometrically designed nanocarrier targeting CDK4/6 and autophagy pathways for effective pancreatic cancer treatment. Nature Communications. doi.org/10.1038/s41467-020-17996-7 （IF=17.694）
13.Yu Gao, Zhihong Li, Xiaodong Xie , Chaoqun Wang, Jiali You, Fan Mo, Biyu Jin, Jianzhong Chen, Jingwei Shao , Haijun Chen, Lee Jia*. Dendrimeric anticancer prodrugs for targeted delivery of ursolic acid to folate recep. European Journal of Pharmaceutical Sciences. 70(2015)55-63. （IF=5.112）
14.Yu Gao, Biyu Jin, Weiyu Shen, Sinko, Xiaodong Xie. China and the United States--Global partners, competitors and collaborators in nanotechnology development. Nanomedicine. 2016 Jan;12(1):13-9. （IF=6.096）
15.Yu Gao, Songen Gu, Yingying Zhang, Xiaodong Xie, Ting Yu, Yusheng Lu, Yewei Zhu, Wenge Chen, Huijuan Zhang, Haiyan Dong, Patrick J. Sinko, and Lee Jia. The Architecture and Function of Monoclonal Antibody-Functionalized Mesoporous Silica Nanoparticles Loaded with Mifepristone: Repurposing Abortifacient for Cancer Metastatic Chemoprevention. Small. 2016 May;12(19):2595-608. （IF=15.153）
16.Fengqiao Li, Hao Mei, Yu Gao, Xiaodong Xie, Huifang Nie, Tao Li, Huijuan Zhang, Lee Jia. Co-delivery of oxygen and erlotinib by aptamer-modified liposomal complexes to reverse hypoxia-induced drug resistance in lung cancer. Biomaterials. 2017 Nov;145:56-71. （IF=15.304）
17.Fengqiao Li, Hao Mei, Xiaodong Xie, Huijuan Zhang, Jian Liu, Tingting Lv, Huifang Nie, Yu Gao, Lee Jia. Aptamer-Conjugated Chitosan-Anchored Liposomal Complexes for Targeted Delivery of Erlotinib to EGFR-Mutated Lung Cancer Cells. AAPS J. 2017 May;19(3):814-826. （IF=3.603）
18.Shu Lian, Yusheng Lu, Yunlong Cheng, Ting Yu, Xiaodong Xie, Haiyang Liang, YuyingYe, Lee Jia*. S-nitrosocaptopril interrupts adhesion of cancer cells to vascular endothelium by suppressing cell adhesion molecules via inhibition of the NF-кB and JAK/STAT signal pathways in endothelial cells. European Journal of Pharmacology. 2016, 791, 62-71.（IF=5.195）
19.Yusheng Lu, Shu Lian, Yuying Ye, Ting Yu, Haiyan Liang, Yunlong Cheng, Jingjing Xie, Yewei Zhu, Xiaodong Xie, Suhong Yu, Yu Gao, Lee Jia*, S-Nitrosocaptopril prevents cancer metastasis in vivo by creating the hostile bloodstream microenvironment against circulating tumor cells. Pharmacological Research. 2019, 139,535-549.（IF=10.334）
20.Yusheng Lu, Shu Lian, Yunlong Cheng, Yuying Ye, Xiaodong Xie, Chengbin Fu, Chen Zhang, Yewei Zhu, M. Iqbal Parker, Lee Jia*. Circulation patterns and seed-soil compatibility factors cooperate to cause cancer organ-specific metastasis. Experimental Cell Research. 2019, 375, 62-72. （IF=4.145）
21.Weiyu Sheng, Yumei Li, Bifei Li, Liping Zheng, Xiaodong Xie, Jingqing Le, Yusheng Lu, Tao Li, Fan Chen, Lee Jia. Downregulation of KCTD12 contributes to melanoma stemness by modulating CD271. 2019 Aug; Cancer Biol Med. 16(3):498-513.（IF=5.347）
专利
高瑜，黎凤乔，梅淏，解晓东，贾力。一种适配体修饰的携氧载药多功能脂质体复合物 201710109979X
